This unified modeling textbook for students of biomedical engineering provides a complete course text on the foundations, theory and practice of modeling and simulation in physiology and medicine. It is dedicated to the needs of biomedical engineering and clinical students, supported by applied BME applications and examples. . Developed for biomedical engineering and related courses: speaks to BME students at a level and in a language appropriate to their needs, with an interdisciplinary clinical/engineering approach, quantitative basis, and many applied examples to enhance learning . Delivers a quantitative approach to modeling and also covers simulation: the perfect foundation text for studies across BME and medicine . Extensive case studies and engineering applications from BME, plus end-of-chapter exercises and a separate Instructor's manual