Contemporary economic scenario sees the prevalence of the service sector in economic systems, the pervasive servitization of manufacturing, innovations in traditional business models and new value creation models, thank to the new possibilities offered by web, ICT and other enabling technologies. Stemming from this evolving context, the book provides qualified contributions on the topic of Service Science in a managerial perspective. A multidisciplinary perspective is adopted in the book: it faces the topic of managing complexity of both the structural-technological and the dynamic-relational aspects. In addressing the contribution that Service Science can provide to the business value creation, the book covers relevant issues such as product servitization, business modelling, value co-creation with customers, performance measures and the role of ICT. It also presents some innovative experiences of management models in service organizations operating in environmental, energy and health care sectors.This book aims to enhance the value of the results of research interwined with the development of a new training curriculum started four years ago with the evolution of the "Master in Management of Innovation" of the Scuola Superiore Sant'Anna of Pisa (Italy) in the new "Master in Management, Innovation and Service Engineering" (MAINS).