This book celebrates the life and work of Peter Nijkamp, whose research provides a strong focus on regional science. His work follows a rigorous, comprehensive approach, centred around analytical modelling and methodological innovation. This edited volume, like Prof Nijkamp’s research, covers a wide range of topics in regional science, analysed through multi-criteria evaluation, evaluation modelling, econometrics, and simulations, among other methods. These tools are applied to the analysis of society and culture, tourism and information, cities, environment and sustainability. Professor Nijkamp is one of the founders and the past president of the Regional Science Association International. His work forms a valuable reference for researchers, scholars, policymakers, and students in the field of regional science and other disciplines. This volume, timed to coincide with his 75th birthday, celebrates Prof Nijkamp’s great contributions to regional science. He also promoted and participated in the education and development of young researchers not only in regional science but also in other fields, supervising many Ph.D. students and hosting even more as guests in Amsterdam. Contributors to this volume include Prof Nijkamp’s former doctoral students and guest researchers, as well as associates and colleagues.